AlthoughThe Big Bang Theory was famous for its comedic setup, at that place were times when the show delved into somber storylines.The Big Blindside Theory tackled deep issues, had sad storylines that pulled at the audience'south heartstrings, and some heartwarming moments that never failed to leave fans in tears.

For the about part,The Big Bang Theory gang stuck together merely once in a while, they went their separate ways. Whether it was over a disagreement between friends, a couple breaking upwards, or something more than permanent like death, in that location were some heartbreaking separations on the evidence.

10 Sheldon Runs Away

Overwhelmed by the changes happening in his life, Sheldon decided to run away from his bug rather than face them in "The Status Quo Combustion." At the fourth dimension, Penny and Leonard were engaged and talking near moving in together and the university was insisting that Sheldon keep his String Theory enquiry. Leonard and Penny somewhen caught up with him at the train station, where he planned to "get on a railroad train and run abroad forever."

Leonard initially tried to talk him out of his plan but Penny convinced him to let Sheldon go. Their part in Sheldon's life straddled the line between parental and friendly, and at that moment it felt like they were watching their son leave for college. The touching goodbye was heartbreaking, at least until Sheldon fabricated a snide improvement afterwards Leonard said he'd miss him.

9 Raj's Parents Divorce

Among the master characters ofThe Big Blindside Theory, Raj was notorious for being the unluckiest when it came to matters of the heart. His misfortunes with beloved seemed to run in his family as his parents divorced in "The Septum Departure." The decline of their relationship was shown gradually, albeit subtly, throughout the show until they finally appear their separation.

At starting time, Raj seemed to be okay with information technology, but when Howard asked him how he was coping, he broke downward. Even though jokes were thrown in to brand the state of affairs lighter and funny, it was notwithstanding sad for the couple to part ways after a long marriage, peculiarly since Raj was trying to think of a gift for their fortieth anniversary at the time.

eight Lucy Breaks Upwardly With Raj

Lucy was one of Raj's first serious girlfriends on the bear witness and also his outset heartbreak. Unable to overcome her social anxiety, Lucy bankrupt things off with Raj in the flavour 6 finale. Heartbroken, Raj cried while Penny comforted him and he ended up speaking for the commencement time in her presence without the assistance of alcohol.

While this was hardly the final time a woman broke upwards with Raj, it was the first ane the audience got to see and the only time he cried. He genuinely liked Lucy and had high hopes of them going the distance, and so it was heartbreaking to see them office ways and how much it crushed him.

7 Sheldon And Amy Breakup

Sheldon and Amy's human relationship was a surprise for both the characters and the audition. Afterwards seasons of focusing on science, comic books, and movies, Sheldon roughshod in love. Information technology took time for Sheldon to even acknowledge he was in a human relationship with Amy, permit alone actually commit to it, but it was heartwarming to see him get in that location.

That's why the audience was heartbroken when Amy broke up with him in "The Commitment Determination," when she felt like he was taking her for granted. While she was completely justified in doing this, that didn't make it hurt any less, especially when the audience discovered Sheldon wanted to propose to her.

half dozen Howard Leaves For Infinite

I of the best, defining moments of Howard's career was when he was chosen to go to the International Space Station. Although it was a positive and exciting thing, he was understandably terrified and Bernadette was sad to see him go. She and the rest of their friends watched the launch of his rocket on the Television receiver, while the scene flashed back to her hymeneals to Howard.

Although it had been their determination to become married before his trip, information technology was quite distressing that they had to separate before they could bask marital bliss. Granted, it was a separation on good terms, merely it was however heartbreaking that they had to be apart, not knowing if Howard would safely get to Space and back.

5 Bernadette Goes To Piece of work

Bernadette struggled with motherhood for a while later having Halley, just she eventually got the hang of information technology. Before long, her maternity leave was over and she had to go back to piece of work and get separated from her girl. While this separation wasn't a permanent one, information technology was definitely an emotional 1 the showtime time effectually.

With Bernadette going back to piece of work, Halley was meant to go to the Caltech daycare center for the solar day. Bernadette said a tearful goodbye to her girl, realizing that she would exist comatose by the fourth dimension she got back home from work. Even Howard and Stuart joined in, making the scene sadder. This kind of separation is i that many new parents are familiar with.

4 Penny And Leonard

Due to their on-and-off relationship, Penny and Leonard went through more breakups than any other couple on the evidence. Later a while, it became less sad and funnier whenever they broke up as the audience knew they would find their way back to each other somewhen. However, one of their separations hit harder than the rest.

Throwing newlyweds into anarchy seems to exist a recurring theme inThe Big Bang Theory every bit Leonard and Penny's spousal relationship almost came to an finish, mere hours after they would have been married. The most heartbreaking matter about this was that they were finally getting their happy-ever-after before disaster struck.

3 Raj Ends His Friendship With Howard

After an insightful chat with his begetter, Raj decided to break things off with Howard because he was e'er making fun of him, stating that their friendship had become toxic. Howard didn't take him seriously at beginning, just Raj held his ground and proceeded to make some changes in his life with his newfound confidence.

Sometimes, a separation can exist the hardest thing to do. However, this one was needed as information technology was in the person'southward best interests. This was one such case.

2 Howard's Mother's Death

Howard lost his female parent in "The Comic Book Store Regeneration," and while the audition never got to see her properly, her constant yelling and remarks made her ane of the funniest characters on the show.

Since she was such a huge part of Howard's life, her death was truly heartbreaking for him. In a one-act likeThe Big Bang Theory, this pitiful moment hitting even harder equally information technology was such a departure from the show's regular funny tone.

1 Sheldon Moves Out

Before Penny came forth, Leonard and Sheldon lived together, fighting occasionally and getting along to some extent. When Leonard and Penny got married and Sheldon and Amy finally officially moved in together, Sheldon was torn up well-nigh it. On 1 hand, he enjoyed living with Amy, but on the other, he missed Leonard.

Sheldon hardly ever shows his emotions, and then the few times he does really pull at the heartstrings. When he finally made the decision to move in permanently with Amy was ane of those moments. Although information technology was long overdue, the change was a large one and certainly a niggling distressing.

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